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KMID : 0377220010260020036
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 2 p.36 ~ p.42
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Diagnostic Availabillty of the Soluble Transferrin Receptor in Iron Deficiency Anemia and Anemia of Chronic Disease using Immunturbidimetric Assay
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Park Young-Jin
Park Geon
Park Sang-Mook
Choi Young-Hwa
Jang Sook-Jin
Moon Dae-Soo
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Abstract
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Background : Soluble transferrin receptor (sTfR) has been known to be a good marker for evaluating iron deficiency anemia (IDA) and anemia of chronic disease (ACD) without bone marrow aspiration. The sTfR has been measured with enzyme linked immunosorbent assay (ELISA). However, Immunoturbidimetric (IT) assay for measuring sTfR was recently introduced. Author try to use clinical application and measure sTfR using IT assay.
Methods : IDA group (26 patients, ferritin ＜ 12.0 μg/L), ACD group (20 patients, ferritin ＞ 60.0 μg/L), Iron depletion and control group (30 normal persons) were classified. Hemoglobin, RBC indices, serum iron, serum transferrin, serum ferritin, total iron binding capacity were measured and calculated. Serum sTfR measured with IT assay using automated chemical analyzer. Those sTfR levels of each other group were compared. The correlations between iron parameters and sTfR were studied in other group.
Results : The sTfR receptor levels were prominently higher in IDA group (5.2 ± 2.2 nmol/L) than in ACD group (1.1 ± 0.8 nmol/L), and normal control group (1.4 ± 0.3 nmol/L). The sTfR levels between ACD group and control group was not different. The correlations between sTfR and Hb levels in IDA group was in good inverse line. Other iron parameters and sTfR levels were not correlated in other groups.
Conclusion : The results indicate that IDA can be differentiated efficiently from ACD with IT method to measure sTfR.
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KEYWORD
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Iron defeficiency anemia, anemia of chronic disease, Soluble transferrin receptor Immunoturbidimetric assay
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